Zonisamide is a drug that is used to treat seizures. It works by lowering the electrical activity in the brain that goes wrong and causes seizures.
Zonisamide is also used for things like migraine headaches and nerve pain that aren’t on the label. It comes in capsules and tablets that you take by mouth. Most people take it once or twice a day.
Zonisamide often causes people to feel dizzy, tired, sick, and lose their appetite. It’s important to take zonisamide as your doctor tells you and to let them know about any side effects or worries.
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Therapeutic Uses Of Zonisamide :
- Monotherapy for partial seizures in adults with epilepsy
- Adjunctive therapy for partial seizures in adults with epilepsy
- Prophylaxis of migraine headaches in adults
Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Therapeutic Uses Of Zonisamide
Adverse Effects Of Zonisamide :
- Hypersensitivity reactions
- Gastrointestinal disturbances
- Renal calculi
- Nausea and vomiting
- Psychomotor slowing
- Skin rash
- Oligohidrosis and hyperthermia
- Cognitive impairment
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Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Adverse Effects Of Zonisamide
Contraindications Of Zonisamide :
- Hypersensitivity to zonisamide or sulfonamides
- History of metabolic acidosis
- Known sulfonamide-induced hypersensitivity reaction
- Renal impairment (creatinine clearance <50 mL/min)
- Pregnancy and breastfeeding
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Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Contraindications Of Zonisamide
Drug Interactions Of Zonisamide :
- Enzyme inducers (e.g. rifampin) may decrease zonisamide levels
- Enzyme inhibitors (e.g. valproic acid) may increase zonisamide levels
- Carbonic anhydrase inhibitors (e.g. acetazolamide) may increase the risk of kidney stones and metabolic acidosis
- CNS depressants (e.g. alcohol, benzodiazepines) may enhance sedative effects of zonisamide.
Mnemonic: European Exam in Core Cardiology