The sublingual way to take a drug is to put a tablet or film under the tongue, where it will dissolve and be absorbed into the bloodstream through the mucous membranes. This is different from giving a drug by mouth, which means swallowing it and letting it go through the digestive system before it gets into the bloodstream.
Drugs that are poorly absorbed by the digestive system or that are quickly broken down by the liver are often given sublingually. Bypassing the digestive system, sublingual administration can make the drug work faster, make it more bioavailable, and make it possible to use smaller doses.
Drugs That Are Administered Sublingually (Mnemonics) :
- Clonazepam – used to treat anxiety, panic disorders, and seizure disorders
- Rizatriptan – used to treat migraines
- Melatonin – used as a sleep aid and to regulate the sleep-wake cycle
- Lorazepam – used to treat anxiety, insomnia, and seizure disorders
- Misoprostol – used to prevent stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs)
- Estradiol – used to treat menopausal symptoms and hormone imbalances
- Glyceryl trinitrate – used to treat heart conditions such as angina and heart failure
- Apomorphine – used to treat Parkinson’s disease
- Fentanyl – used to treat severe pain
- Liothyronine – used to treat hypothyroidism
- Ondansetron – used to prevent and treat nausea and vomiting caused by chemotherapy and radiation therapy
- Prochlorperazine – used to treat nausea and vomiting
- Vitamin B12 – used to treat vitamin deficiencies, anemia, and neuropathy.
- Buprenorphine – used to treat opioid dependence and pain management
- Pilocarpine – used to treat dry mouth and eye conditions
- Nitroglycerin – used to treat angina or chest pain associated with heart disease
- Naloxone – used to reverse the effects of opioid overdose.
- Zolpidem – used as a sleep aid to treat insomnia
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