You are currently viewing Semantic Primary Progressive Aphasia Mnemonic

Here is a quick mnemonic “SEMANTIC to remember about Semantic  Primary Progressive Aphasia

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, MBBS, NEET PG, FMGE, NExT, MCAT & NCLEX exams

Semantic Primary Progressive Aphasia : How To Remember Easily ?

  • S – Speech is usually informative and repetition is intact.
  • E – Excludes Wernicke’s aphasia or posterior transcortical aphasia.
  • M – Meaningful sentences are relatively preserved.
  • A – Anterior temporal lobe atrophy is a common feature.
  • N – Not seen with CVAs (cerebrovascular accidents).
  • T – Two-way naming impairments are profound.
  • I – Informal conversations may appear unimpaired.
  • C – Comprehension is poor for single words.
  • A – Aphasia characterized by preserved fluency and syntax.
  • P – Patients may surmise the gist through contextual cues.
  • H – Hemispheric lesion is usually absent.
  • A – Abnormal TDP-43 pathology is frequently observed.
  • S – Site of atrophy plays a critical role in word comprehension.
  • I – Impaired comprehension of words denoting concrete objects.
  • A – Atrophy in the left anterior temporal lobe.


Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department