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Here is a quick mnemonic ” PROTEINS  to remember about the Pyrogenic Cytokines In Fever Pathogenesis

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, NEET PG, FMGE, NExT & NCLEX exams

Pyrogenic cytokines play a crucial role in the development of fever. These are a class of signaling molecules that are released by immune cells in response to infection, inflammation, or injury. Pyrogenic cytokines are capable of inducing fever by acting on the hypothalamus, which is the part of the brain that regulates body temperature.

The most important pyrogenic cytokines involved in fever are interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). These cytokines are produced by activated immune cells such as macrophages, dendritic cells, and monocytes.

Pyrogenic Cytokines In Fever Pathogenesis : How To Remember Easily ?

  • P – Pyrogenic cytokines, including IL-1, IL-6, TNF, and ciliary neurotropic factor, can cause fever.
  • R – Regulate immune, inflammatory, and hematopoietic processes.
  • O – Outbreaks of several infections with an absolute neutrophilia are due to cytokines IL-1 and IL-6.
  • T – Tumor necrosis factor (TNF) is a pyrogenic cytokine that can cause fever.
  • E – Each pyrogenic cytokine is encoded by a separate gene and can cause fever in laboratory animals and humans.
  • I – Interleukin (IL) 1 and IL-6 produce fever when injected at low doses into humans.
  • N – Neutrophilia seen in infections is due to cytokines IL-1 and IL-6.
  • S – Synthesis and release of pyrogenic cytokines can be induced by bacterial and fungal products.

Mnemonic :  PROTEINS

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department