You are currently viewing Pain : Primary Afferent Nociceptor Mnemonics [Remember Easily]

Medical and nursing students may find the mnemonic “PAIN TRPV1” helpful because it provides a concise summary of The Primary Afferent Nociceptor.

One type of sensory neuron, called a primary afferent nociceptor, is in charge of picking up and relaying pain signals to the brain. These nociceptors are activated in response to painfully strong stimuli such temperature extremes, mechanical deformation, pH shifts, and chemical irritants.

Students can remember the function of nociceptors in pain perception, the different types of stimuli that activate them, and the different fiber diameters, myelination levels, and conduction velocities by just memorizing the acronym.

The mnemonic also serves to draw attention to the role played by the TRPV1 receptor in mediating the experience of pain. Students can better retain and use this information in their studies and future careers caring for patients in pain by employing the mnemonic.

The Primary Afferent Nociceptor Mnemonics :

  • PAIN

    • Primary afferent nociceptors are responsible for the subjective experience of pain
    • Aδ and C fiber afferents are nociceptors
    • Intense (painful) stimuli activate Aδ and C fibers
    • Nociceptors respond to heat, cold, mechanical distortion, changes in pH, and chemical irritants


    • Transient receptor potential cation channel subfamily V member 1 (TRPV1) mediates perception of some noxious stimuli
    • TRPV1 is activated by heat, acidic pH, endogenous mediators, and capsaicin

Mnemonic: PAIN TRPV1″


Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER working in department