Medical and nursing students may find the mnemonic “NOISE” helpful because it summarizes the most important aspects of nociceptor-induced inflammation. Students can use this mnemonic to help them remember key concepts like nociceptors, polypeptide mediators, inflammation, and the effects of substance P on tissues while they study this topic.
This can improve their ability to remember the material and put it to use in patient care. The mnemonic is also useful for a speedy review of the material before exams or when meeting applicable clinical settings.
When triggered, nociceptors (sensory nerve fibers that respond to painful stimuli) produce polypeptide mediators that can cause inflammation in the affected tissues; this process is known as nociceptors-induced inflammation.
One such mediator is substance P, which is secreted by activated nociceptors and has been shown to trigger a variety of inflammatory responses including vasodilation, mast cell degranulation, leukocyte chemotaxis, and the release of additional inflammatory mediators. Substance P deficiency in the joints has been linked to a milder form of experimental arthritis.
Pain – Nociceptor-Induced Inflammation Mnemonics :
- N – Nociceptors play an active role in tissue protection
- O – Polypeptide mediators (Substance P, CGRP, and Cholecystokinin) are released from nociceptor peripheral terminals when activated
- I – Inflammatory mediators are produced and released
- S – Substance P has multiple biological activities, including vasodilation, mast cell degranulation, and leukocyte chemoattraction
- E – Experimental arthritis severity is reduced with depletion of Substance P from joints.