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The mnemonic “CLOVER” will definitely help you in remembering the Opioid and COX Inhibitor Combinations In Acute Pain Management

To help you to recall better we have used related words that are very close to the actual disease itself, thus helping you to relate well 

Opioid and COX (cyclooxygenase) inhibitor combinations are commonly used in acute pain management to provide effective analgesia while minimizing the adverse effects of opioids. The combination of opioids, which are potent pain-relieving medications, with COX inhibitors, which are nonsteroidal anti-inflammatory drugs (NSAIDs) that reduce inflammation and pain, can provide synergistic effects, resulting in improved pain relief.

Opioid and COX Inhibitor Combinations In Acute Pain Management : How To Remember Easily ?

  • C – Combinations: Opioids and COX inhibitors have additive effects when used together.
  • L – Lower Dose: Lower doses of opioids and COX inhibitors can achieve the same degree of pain relief.
  • O – Nonadditive Side Effects: The side effects of opioids and COX inhibitors are nonadditive.
  • V – Variable Combinations: Fixed-ratio combinations of opioids with acetaminophen carry a risk of toxicity.
  • E – Escalation: Dose escalation due to increased pain severity or tolerance can lead to liver toxicity.
  • R – Rare but Significant: Acetaminophen-related hepatotoxicity is uncommon but remains a significant cause of liver failure.

Mnemonic : CLOVER

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department
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