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Here is a quick mnemonic “NACROLEPSY REM SLEEP to remember about Narcolepsy

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, MBBS, NEET PG, FMGE, NExT, MCAT & NCLEX exams

Narcolepsy : How To Remember Easily ?

  • N – Narcolepsy is characterized by difficulty sustaining wakefulness.
  • A – All patients with narcolepsy have excessive daytime sleepiness.
  • R – REM sleep regulation is poor in narcolepsy.
  • C – Cataplexy, sudden muscle weakness, is a symptom of narcolepsy.
  • O – Orexin neuropeptides are lost in narcolepsy.
  • L – Loss of orexin signaling causes frequent sleep intrusions.
  • E – Excessive daytime sleepiness is a common symptom of narcolepsy.
  • P – People with narcolepsy usually feel well-rested upon awakening but feel tired throughout the day.
  • S – Sleep paralysis is a characteristic symptom of narcolepsy.
  • Y – Young individuals between the ages of 10 and 20 are typically affected by narcolepsy.
  • R – Research shows a loss of orexin-producing neurons in narcolepsy.
  • E – Excessive daytime sleepiness is a major complaint of narcolepsy patients.
  • M – Orexins promote wakefulness and suppress REM sleep.
  • S – Selective loss of orexin-producing neurons occurs in narcolepsy.
  • L – Low or undetectable levels of orexins are found in CSF of narcolepsy patients.
  • E – Episodes of sleep intrusion and fragments of REM sleep occur in narcolepsy.
  • E – Evidence suggests an autoimmune process is involved in narcolepsy.
  • P – People with narcolepsy may have an autoimmune response against orexin.


Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department