You are currently viewing Mechanisms Of Antipyretic Agents In Fever : Mnemonic

Here is a quick mnemonic ” INHIBITOR  to remember about the Mechanisms Of Antipyretic Agents In Fever

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, NEET PG, FMGE, NExT & NCLEX exams

Antipyretic agents are drugs used to lower elevated body temperature or fever. Fever is an adaptive response to an underlying infection or inflammation, which is characterized by an increase in body temperature. The mechanisms of action of antipyretic agents involve their ability to inhibit the production of prostaglandins, which are mediators involved in the regulation of body temperature.

Mechanisms Of Antipyretic Agents In Fever : How To Remember Easily ?

  • I – Inhibition of PGE2 synthesis is the key to reducing fever.
  • N – NSAIDs such as ibuprofen and specific inhibitors of COX-2 are excellent antipyretics.
  • H – High-dose therapy with antipyretics such as aspirin or any NSAID does not reduce normal core body temperature.
  • I – In the brain, acetaminophen is oxidized by the P450 cytochrome system, and the oxidized form inhibits cyclooxygenase activity.
  • B – Block the transcription of the mRNA for the pyrogenic cytokines is how glucocorticoids act at the second level to reduce fever.
  • I – Ibuprofen and COX-2 inhibitors reduce IL-1-induced IL-6 production and may contribute to the antipyretic activity of NSAIDs.
  • T – The synthesis of PGE2 depends on the constitutively expressed enzyme cyclooxygenase.
  • O – Oral aspirin and acetaminophen are equally effective in reducing fever in humans.
  • R – Release of arachidonic acid from the cell membrane is the rate-limiting step in the synthesis of PGE2 and is needed for cyclooxygenase to work.

Mnemonic :  INHIBITOR

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department