Linezolid is an antibiotic used to treat a wide range of bacterial infections, such as pneumonia, skin infections, and bloodstream infections. It is a man-made antibiotic that works by stopping bacteria from making proteins by binding to the 23S ribosomal RNA on the bacterial ribosome.
Linezolid can be taken by mouth or given through a vein. It is usually used for short-term treatment, usually for 10 to 14 days. It is usually well tolerated, with diarrhea, nausea, headaches, and vomiting being the most common side effects.
It’s important to know that linezolid can react badly with some drugs, especially antidepressants, and cause serious side effects like serotonin syndrome. Before starting treatment with linezolid, it is important to tell your doctor about all the medicines you are already taking.
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Therapeutic Uses Of Linezolid :
- Vancomycin-resistant Enterococcus faecium infections
- Nosocomial pneumonia
- Bone and joint infections
- Community-acquired pneumonia
- Skin and soft tissue infections
- Treatment of infections caused by Gram-positive bacteria
- Complicated skin and soft tissue infections
- Methicillin-resistant Staphylococcus aureus (MRSA) infections
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Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Therapeutic Uses Of Linezolid
Adverse Effects Of Linezolid :
- Headache
- Anorexia
- Nausea
- Dizziness
- Skin rash
- Thrombocytopenia
- Peripheral neuropathy
- Ataxia
- Serotonin syndrome
- Seizures
- Leukopenia
- Oligohidrosis and hyperthermia
- Vomiting
- Psychiatric disturbances
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Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Adverse Effects Of Linezolid
Contraindications Of Linezolid :
- Use of MAO inhibitors within two weeks
- Pheochromocytoma
- Adrenal gland tumor
- Thyroid cancer
- Hypersensitivity to linezolid
- Uncontrolled hypertension
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Mind Map / Concept Map /Memory Aid/ Mnemonic To Remember Contraindications Of Linezolid
Drug Interactions Of Linezolid :
- Serotonin reuptake inhibitors
- Beta-blockers
- Adrenergic agents
- Dopaminergic agents
- MAO inhibitors
- Linezolid may enhance the effects of certain drugs that increase blood pressure, such as epinephrine and norepinephrine.
- Sympathomimetic agents
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