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Here is a quick mnemonic “LEBER’S OPTIC to remember about Leber’s Hereditary Optic Neuropathy

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, MBBS, NEET PG, FMGE, NExT, MCAT & NCLEX exams

Leber’s Hereditary Optic Neuropathy : How To Remember Easily ?

  • L – Leber’s hereditary optic neuropathy affects young men, causing visual loss.
  • E – Each eye is affected sequentially, with the second eye following the first.
  • B – Both eyes experience painless, progressive central visual loss.
  • E – Eventually, optic atrophy develops.
  • R – The optic disc appears plethoric with telangiectasias but no leakage.
  • S – Surface capillary telangiectasias are observed on fluorescein angiography.
  • O – Optic atrophy is a characteristic feature of Leber’s optic neuropathy.
  • P – Point mutation at codon 11778 in mitochondrial gene causes the disease.
  • T – The mitochondrial gene encodes the NADH subunit 4.
  • I – It is inherited maternally and affects both eyes.
  • C – Clinical trials for gene therapy have been unsuccessful.

Mnemonic : LEBER’S OPTIC

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department