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Here is a quick mnemonic ” SET POINT  to remember about the Hypothalamic Set Point Elevation By Cytokines

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, NEET PG, FMGE, NExT & NCLEX exams

The hypothalamic set point is a concept in physiology that refers to the temperature range that the body maintains through a variety of physiological processes. It is regulated by the hypothalamus, a region of the brain that plays a crucial role in maintaining homeostasis in the body.

Cytokines are a type of signaling molecule that plays an important role in the immune system’s response to infections and inflammation. They are produced by immune cells and other cells in the body and act on various cells to modulate the immune response.

Hypothalamic Set Point Elevation By Cytokines : How To Remember Easily ?

  • S: Set point is the term used to describe the temperature at which the body’s thermoregulatory center is set during a fever.

  • E: Elevated levels of prostaglandin E2 (PGE2) are found in the hypothalamic tissue and the third cerebral ventricle during fever.

  • T: The third receptor for PGE2, EP-3, is essential for fever, while the other receptor genes can be deleted without affecting the fever mechanism.

  • P: Pyrogenic cytokines, such as IL-1, IL-6, and TNF, induce the synthesis of PGE2, which leads to fever.

  • O: Organum vasculosum of lamina terminalis (OVLT) is a network of enlarged capillaries surrounding the hypothalamic regulatory centers, and destruction of these organs reduces the ability of pyrogens to produce fever.

  • I: It is thought that some systemic PGE2 escapes destruction by the lung and gains access to the hypothalamus via the internal carotid.

  • N: Nonspecific myalgias and arthralgias often accompany fever due to an increase in PGE2 in peripheral tissues.

  • T: Toll-like receptors, located on the hypothalamic endothelium, are similar to IL-1 receptors and result in PGE2 production and fever when directly activated.

Mnemonic :  SET POINT

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department