Erythema Multiforme Rash Mnemonic : [NEVER FORGET AGAIN]

M – Multiple causes for erythema multiforme, including infection, drugs, and idiopathic factors.

U – Unusual target lesions seen in erythema multiforme, characterized by central erythema surrounded by an area of clearing and another rim of erythema.

L – Lesions typically measure up to 2 cm and appear symmetrically on the knees, elbows, palms, and soles in erythema multiforme.

T – The rash spreads centripetally and can be papular, sometimes vesicular, in erythema multiforme.

I – Involvement of mucous membranes in erythema multiforme, when extensive, is termed EM major.

F – Frequently associated with herpes simplex virus or Mycoplasma pneumoniae infection and certain drugs like sulfa, phenytoin, and penicillin.

O – Over 50% of patients with erythema multiforme are younger than 20 years old, and fever is more common in the most severe form, EM major.

R – Recognizing the distinction between EM major and Stevens-Johnson syndrome is crucial, as EM major lacks prominent skin sloughing.

M – Multiple causes, unusual target lesions, limited size, spreading pattern, mucous membrane involvement, associated infections and drugs, age group, and distinguishing from Stevens-Johnson syndrome.

E – Erythema multiforme, a distinct clinical entity with its characteristic manifestations and potential triggers.