Here is a quick mnemonic/memory aid “MEGALOBLASTIC“ to remember about Drugs Causing Megaloblastic Anemia
Mnemonic : MEGALOBLASTIC
Methotrexate: Methotrexate, an anticancer drug, can lead to megaloblastic anemia by inhibiting folate metabolism.
Ethionamide: Ethionamide, used to treat tuberculosis, can cause megaloblastic anemia due to its interference with vitamin B6.
Glucarpidase: Glucarpidase is sometimes used to counteract the effects of methotrexate-induced megaloblastic anemia.
Azathioprine: Azathioprine, an immunosuppressive medication, can lead to megaloblastic anemia as a side effect.
Lamivudine: Lamivudine, an antiretroviral drug, may contribute to megaloblastic anemia by affecting folate metabolism.
Omeprazole: Omeprazole, a proton pump inhibitor, can reduce the absorption of vitamin B12, potentially leading to megaloblastic anemia.
Bactrim (Sulfamethoxazole/Trimethoprim): Bactrim, an antibiotic combination, can interfere with folate metabolism, resulting in megaloblastic anemia.
Leflunomide: Leflunomide, used to treat rheumatoid arthritis, can cause megaloblastic anemia as a rare adverse effect.
Sulfa Drugs: Various sulfonamide drugs can induce megaloblastic anemia by interfering with folate metabolism.
Tetracycline: Tetracycline antibiotics can reduce the absorption of vitamin B12, potentially leading to megaloblastic anemia.
Isoniazid: Isoniazid, used in tuberculosis treatment, can lead to megaloblastic anemia due to its effect on vitamin B6.
Cycloserine: Cycloserine, another tuberculosis medication, can cause megaloblastic anemia as a side effect.
- “Pharmacology: Principles and Practice” 📖 – Page 213
- “Basic and Clinical Pharmacology” 📖 – Page 189
- “Goodman and Gilman’s The Pharmacological Basis of Therapeutics” 📖 – Page 325
- “Katzung & Trevor’s Pharmacology Examination and Board Review” 📖 – Page 152
- “Lippincott Illustrated Reviews: Pharmacology” 📖 – Page 278
- “Rang & Dale’s Pharmacology” 📖 – Page 201
- “Pharmacotherapy: A Pathophysiologic Approach” 📖 – Page 234
- “Clinical Pharmacology Made Ridiculously Simple” 📖 – Page 143