Here is a quick mnemonic/memory aid “HYPERPLASIA“ to remember about Drugs Causing Adrenal Hyperplasia
Mnemonic : HYPERPLASIA
H – Heparin: Heparin is known to cause adrenal hyperplasia by suppressing the synthesis of adrenal steroids.
Y – Yohimbine: Yohimbine, an alpha-2 adrenergic receptor antagonist, can lead to adrenal hyperplasia through its effects on the adrenal glands.
P – Phenytoin: Phenytoin, an antiepileptic medication, has been associated with adrenal hyperplasia in some cases due to its influence on adrenal steroid metabolism.
E – Estrogens: Certain estrogen-containing medications, such as oral contraceptives, may contribute to adrenal hyperplasia by altering hormone levels.
R – Rifampin: Rifampin, an antibiotic used to treat tuberculosis, can induce adrenal hyperplasia by affecting adrenal steroid synthesis.
P – Progestins: Some progestin-based medications, like medroxyprogesterone, have been linked to adrenal hyperplasia due to their hormonal effects.
L – L-asparaginase: L-asparaginase, an enzyme used in cancer treatment, can cause adrenal hyperplasia as a rare side effect.
A – Aminoglutethimide: Aminoglutethimide, used to treat Cushing’s syndrome, may lead to adrenal hyperplasia as it inhibits adrenal steroid production.
S – Steroids: Long-term use of corticosteroids, such as prednisone, can result in adrenal hyperplasia due to suppression of the adrenal glands.
I – Insulin: Excessive insulin administration, especially in insulinomas, can cause adrenal hyperplasia as insulin affects adrenal function.
A – ACE Inhibitors: Angiotensin-converting enzyme (ACE) inhibitors like enalapril may rarely lead to adrenal hyperplasia as a side effect.
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