Drugs Causing Adrenal Hyperplasia⚡Mnemonic⚡

Mnemonic :  HYPERPLASIA

H – Heparin: Heparin is known to cause adrenal hyperplasia by suppressing the synthesis of adrenal steroids.

Y – Yohimbine: Yohimbine, an alpha-2 adrenergic receptor antagonist, can lead to adrenal hyperplasia through its effects on the adrenal glands.

P – Phenytoin: Phenytoin, an antiepileptic medication, has been associated with adrenal hyperplasia in some cases due to its influence on adrenal steroid metabolism.

E – Estrogens: Certain estrogen-containing medications, such as oral contraceptives, may contribute to adrenal hyperplasia by altering hormone levels.

R – Rifampin: Rifampin, an antibiotic used to treat tuberculosis, can induce adrenal hyperplasia by affecting adrenal steroid synthesis.

P – Progestins: Some progestin-based medications, like medroxyprogesterone, have been linked to adrenal hyperplasia due to their hormonal effects.

L – L-asparaginase: L-asparaginase, an enzyme used in cancer treatment, can cause adrenal hyperplasia as a rare side effect.

A – Aminoglutethimide: Aminoglutethimide, used to treat Cushing’s syndrome, may lead to adrenal hyperplasia as it inhibits adrenal steroid production.

S – Steroids: Long-term use of corticosteroids, such as prednisone, can result in adrenal hyperplasia due to suppression of the adrenal glands.

I – Insulin: Excessive insulin administration, especially in insulinomas, can cause adrenal hyperplasia as insulin affects adrenal function.

A – ACE Inhibitors: Angiotensin-converting enzyme (ACE) inhibitors like enalapril may rarely lead to adrenal hyperplasia as a side effect.