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Here is a quick mnemonic “COMMON MANIFESTATION to remember about Differential Diagnosis Of Fatigue

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, NEET PG, FMGE, NExT & NCLEX exams

Differential Diagnosis Of Fatigue : How To Remember Easily ?

  • C – Chronic illness often leads to fatigue as a common manifestation.
  • O – Obstructive sleep apnea is associated with fatigue and sleepiness.
  • M – Muscle weakness can be a cardinal manifestation of certain diseases.
  • M – Malnutrition and low vitamin D status contribute to fatigue.
  • O – Obesity is linked to fatigue and physical inactivity.
  • N – Neurologic disorders frequently exhibit fatigue as a symptom.
  • M – Many medications and drugs can cause fatigue.
  • A – Adrenal insufficiency and endocrine disorders are associated with fatigue.
  • N – Numerous infections, both acute and chronic, lead to fatigue.
  • I – Inflammatory disorders and immune-mediated diseases often include fatigue.
  • F – Fatigue is a prominent complaint in malignancies and hematologic disorders.
  • E – Excessive daytime sleepiness is a common manifestation of sleep disorders.
  • S – Chronic fatigue syndrome and fibromyalgia incorporate fatigue as a defining feature.
  • T – Thyroid dysfunction, hypoglycemia, and liver/kidney disease can cause fatigue.
  • A – Anemia and chronic illness contribute to fatigue.
  • T – Tuberculosis, HIV, and other infections should be considered as causes of fatigue.
  • I – Inactivity worsens fatigue, while increasing physical activity can help.
  • O – Other factors such as depression and alcohol use can also lead to fatigue.
  • N – Fatigue is commonly reported during pregnancy.


Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER working in department