You are currently viewing Coma Due to Metabolic, Drug, and Toxic Disorders Mnemonic

Here is a quick mnemonic “COMA DUE TO DRUG to remember about Coma Due to Metabolic, Drug, and Toxic Disorders

This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, MBBS, NEET PG, FMGE, NExT, MCAT & NCLEX exams

Coma Due to Metabolic, Drug, and Toxic Disorders : How To Remember Easily ?

  • C – Cerebral neurons are dependent on cerebral blood flow (CBF) and the delivery of oxygen and glucose.
  • O – Oxygen stores last 8-10 s after the cessation of blood flow.
  • M – Metabolic abnormalities cause coma by interrupting the delivery of energy substrates or by altering neuronal excitability.
  • A – Anesthesia, alcohol, and epilepsy are examples of drugs that can cause coma.
  • DDrugs and toxins are capable of depressing nervous system function.
  • U – Unlike hypoxia-ischemia, which first causes a metabolic encephalopathy, most metabolic disorders cause no or only minor neuropathologic changes in the brain.
  • E – Energy substrate delivery worsens, eventually causing brain electrical activity to cease.
  • T – The reversible effects of metabolic abnormalities may result from impaired energy supplies, changes in ion fluxes, and neurotransmitter abnormalities.
  • O – Over time, development of a diffuse astrocytosis is typical of chronic hepatic encephalopathy.
  • D – Depletion of catecholamines and altered glutamate and GABA tone contribute to uremic encephalopathy.
  • R – Renal failure can lead to encephalopathy due to accumulation of neurotoxic substances and disruption of the blood-brain barrier.
  • U – Uremic encephalopathy is uncertain and likely to be multifactorial.
  • G – Glutamine synthesis, osmotic swelling of astrocytes, and mitochondrial energy failure contribute to hepatic encephalopathy.


Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department