Here is a quick mnemonic ” REDUCE FEVER “ to remember about the Therapeutic use of anticytokine agents for fever reduction in individuals with autoimmune and autoinflammatory conditions
This can be valuable for patients as well as medical doctors, nurses & students doing their clinical rounds. You can also find it very useful for med exams like USMLE, NEET PG, FMGE, NExT & NCLEX exams
Fever is a common symptom of autoimmune and autoinflammatory diseases, which are conditions in which the immune system mistakenly attacks the body’s own tissues. In these conditions, the immune system produces excess levels of cytokines, which are small proteins that play a key role in regulating the immune response. Excessive cytokine production can lead to systemic inflammation, fever, and tissue damage.
Anticytokine therapy is a type of treatment that aims to reduce fever and inflammation in autoimmune and autoinflammatory diseases by blocking the action of specific cytokines. This can be done using monoclonal antibodies, which are engineered proteins that specifically bind to and neutralize cytokines in the blood.
Anticytokine Therapy To Reduce Fever In Autoimmune And Autoinflammatory Diseases : How To Remember Easily ?
R – Recurrent fever is documented in many autoimmune and autoinflammatory diseases.
E – Autoinflammatory diseases are characterized by recurrent fevers and serosal inflammation.
D – Diseases such as Still’s disease, familial Mediterranean fever, and hyper-IgD syndrome are examples of autoinflammatory diseases with recurrent fevers.
U – Uncommon and common diseases such as idiopathic pericarditis and gout can also cause recurrent fevers.
C – Canakinumab and anakinra are effective in reducing fevers associated with autoinflammatory diseases by blocking IL-1 activity.
E – Even though fevers in autoinflammatory diseases are mediated by IL-1β, patients also respond to antipyretics.
F – Fevers are a common manifestation of autoinflammatory diseases.
E – Excessive neutrophil counts and serosal inflammation also characterize autoinflammatory diseases.
V – Various components of the innate immune system, including inflammasomes (e.g., NLRP3, pyrin), are involved in autoinflammatory diseases.
E – Elevated levels of cytokines are associated with fever in autoimmune and autoinflammatory diseases.
R – Recurrent fevers are a characteristic feature of autoinflammatory diseases.
Mnemonic : REDUCE FEVER