Here is a quick mnemonic/memory aid “SLEEP ZONE to remember about the Drugs Causing Obstructive Sleep Apnea

S – Sedatives: Medications like benzodiazepines (e.g., diazepam) can relax throat muscles and contribute to OSA.

L – Lead: Heavy metals like lead can lead to OSA by affecting the central nervous system.

E – Ethanol: Excessive alcohol consumption, especially in the evening, can lead to OSA as it relaxes the upper airway muscles.

E – Estrogens: Hormone replacement therapy (estrogens) may increase the risk of OSA in postmenopausal women.

P – Phenytoin: This antiepileptic drug can contribute to OSA by affecting muscle tone.

Z – Zolpidem: A common sleep aid, zolpidem, can relax the throat muscles and worsen OSA.

O – Opioids: Medications like morphine and codeine can depress the respiratory drive and contribute to OSA.

N – Nitrates: Nitroglycerin and other nitrates can cause OSA due to their muscle-relaxing effects.

E – Epinephrine: Excessive use of epinephrine-containing nasal decongestants can lead to OSA by constricting blood vessels and reducing airflow.

⚡Mnemonic⚡Drugs Causing Obstructive Sleep Apnea

  • “Obstructive Sleep Apnea: A Clinical Guide” (3rd Edition) 📚 Pg. 134

  • “Diagnosis and Management of Adult Obstructive Sleep Apnea” (Latest Edition) 📚 Pg. 88

  • “Sleep Apnea: Current Diagnosis and Treatment” (5th Edition) 📚 Pg. 197

  • “Advances in Sleep Apnea: Understanding Mechanisms and Treatment” 📚 Pg. 56

  • “Obstructive Sleep Apnea: Pathophysiology, Comorbidities, and Consequences” (2nd Edition) 📚 Pg. 112

  • “Pediatric Sleep Medicine: Expert Consult – Online and Print” (Latest Edition) 📚 Pg. 153

  • “Obstructive Sleep Apnea: Clinical Features, Pathophysiology, and Treatment” (4th Edition) 📚 Pg. 82

  • “Sleep Disorders and Sleep Promotion in Nursing Practice” (Latest Edition) 📚 Pg. 120

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department