⚡Mnemonic⚡: Differential Diagnosis of Alport Syndrome

Mnemonic :  DIFFERENTIAL

D – “Doughy Eye” – Consider conditions associated with corneal opacity, like Meesmann corneal dystrophy, which can mimic certain eye symptoms of Alport Syndrome.

I – “IgA Nephropathy” – Differentiate from IgA nephropathy, which can also cause hematuria and proteinuria.

F – “Familial Hematuria” – Look for a family history of isolated hematuria, as Alport Syndrome often has a hereditary pattern.

F – “Fechtner Syndrome” – Rule out Fechtner syndrome, a rare condition that can present with kidney and hearing issues.

E – “Epithelial Microcysts” – In some cases, Alport Syndrome may present with epithelial microcysts in the cornea, which can be mistaken for other eye conditions.

R – “Renal Tubular Acidosis” – Exclude renal tubular acidosis, which can cause metabolic acidosis and kidney issues, similar to Alport Syndrome.

E – “Ehlers-Danlos Syndrome” – Distinguish from Ehlers-Danlos syndrome, which can also affect collagen and cause skin and joint hypermobility.

N – “Nail-Patella Syndrome” – Consider nail-patella syndrome, which can cause kidney abnormalities and joint issues.

T – “Thin Basement Membrane Disease” – Be sure to differentiate from thin basement membrane disease, a milder condition that can resemble Alport Syndrome.

I – “IgG Nephropathy” – Exclude IgG nephropathy, another condition that can lead to kidney problems and hematuria.

A – “Alport Syndrome” – Last but not least, confirm the diagnosis of Alport Syndrome through genetic testing, if necessary.

L – (Blank)