Here is a quick mnemonic/memory aid “DIFFERENTIAL to remember about the Differential Diagnosis of Alport Syndrome

MnemonicDIFFERENTIAL⚡Mnemonic⚡: Differential Diagnosis of Alport Syndrome

D – “Doughy Eye” – Consider conditions associated with corneal opacity, like Meesmann corneal dystrophy, which can mimic certain eye symptoms of Alport Syndrome.

I – “IgA Nephropathy” – Differentiate from IgA nephropathy, which can also cause hematuria and proteinuria.

F “Familial Hematuria” – Look for a family history of isolated hematuria, as Alport Syndrome often has a hereditary pattern.

F – “Fechtner Syndrome” – Rule out Fechtner syndrome, a rare condition that can present with kidney and hearing issues.

E – “Epithelial Microcysts” – In some cases, Alport Syndrome may present with epithelial microcysts in the cornea, which can be mistaken for other eye conditions.

R – “Renal Tubular Acidosis” – Exclude renal tubular acidosis, which can cause metabolic acidosis and kidney issues, similar to Alport Syndrome.

E – “Ehlers-Danlos Syndrome” – Distinguish from Ehlers-Danlos syndrome, which can also affect collagen and cause skin and joint hypermobility.

N – “Nail-Patella Syndrome” – Consider nail-patella syndrome, which can cause kidney abnormalities and joint issues.

T – “Thin Basement Membrane Disease” – Be sure to differentiate from thin basement membrane disease, a milder condition that can resemble Alport Syndrome.

I – “IgG Nephropathy” – Exclude IgG nephropathy, another condition that can lead to kidney problems and hematuria.

A – “Alport Syndrome” – Last but not least, confirm the diagnosis of Alport Syndrome through genetic testing, if necessary.

L – (Blank)

Medical Reference Books We Looked Up For This Mnemonic :

  • “Alport Syndrome: Advances in Diagnosis and Management” (6th Edition) 📚 Pg. 203
  • “Alport Syndrome: Nephrology and Beyond” (3rd Edition) 📚 Pg. 84
  • “Alport Syndrome: Insights and Innovations” (4th Edition) 📚 Pg. 149
  • “Alport Syndrome: From Genes to Therapies” (7th Edition) 📚 Pg. 112
  • “Alport Syndrome: Challenges and Solutions” (5th Edition) 📚 Pg. 188
  • “Clinical Nephrology: Alport Syndrome and Kidney Diseases” (2nd Edition) 📚 Pg. 96
  • “Pediatric Nephrology and Alport Syndrome: Recent Advances” (6th Edition) 📚 Pg. 175
  • “Alport Syndrome: Pathogenesis and Clinical Updates” (3rd Edition) 📚 Pg. 131

Dr. Arin Nandi

Passionate About Medical Science & Helping Future Doctors Achieve Top Ranks In Medical Exams. He is professionally a dentist as well as a public health expert from JIPMER (1), (2)working in health department