⚡Mnemonic⚡: Causes of Alport Syndrome

Mnemonic :  ALPORT

A – Alpha-5 Chain Mutation: Remember, Alport Syndrome can be caused by mutations in the COL4A5 gene, leading to a faulty alpha-5 chain.

L – Lamellated Glomerular Basement Membrane: Think of the “L” as the layers in “Lamellated.” In Alport Syndrome, there’s a characteristic splitting and lamellation of the glomerular basement membrane.

P – Proteinuria: P for Proteinuria, a common symptom in Alport Syndrome due to the impaired filtration function of the kidneys.

O – Ocular Abnormalities: O reminds us of the eyes. Alport Syndrome can present with ocular abnormalities such as anterior lenticonus or posterior polymorphous corneal dystrophy.

R – Renal Failure: R signifies Renal Failure. Over time, Alport Syndrome can progress to renal failure, a serious consequence of the disease.

T – Thin Basement Membrane Nephropathy (TBMD): T is for Thin Basement Membrane Nephropathy, a related condition. Alport Syndrome can sometimes be associated with TBMD due to mutations in collagen.