Here is a quick mnemonic/memory aid “ALPORT“ to remember about the Causes of Alport Syndrome
Mnemonic : ALPORT
A – Alpha-5 Chain Mutation: Remember, Alport Syndrome can be caused by mutations in the COL4A5 gene, leading to a faulty alpha-5 chain.
L – Lamellated Glomerular Basement Membrane: Think of the “L” as the layers in “Lamellated.” In Alport Syndrome, there’s a characteristic splitting and lamellation of the glomerular basement membrane.
P – Proteinuria: P for Proteinuria, a common symptom in Alport Syndrome due to the impaired filtration function of the kidneys.
O – Ocular Abnormalities: O reminds us of the eyes. Alport Syndrome can present with ocular abnormalities such as anterior lenticonus or posterior polymorphous corneal dystrophy.
R – Renal Failure: R signifies Renal Failure. Over time, Alport Syndrome can progress to renal failure, a serious consequence of the disease.
T – Thin Basement Membrane Nephropathy (TBMD): T is for Thin Basement Membrane Nephropathy, a related condition. Alport Syndrome can sometimes be associated with TBMD due to mutations in collagen.
Medical Reference Books We Looked Up For This Mnemonic :
- “Alport Syndrome: Genetics and Clinical Diagnosis” (6th Edition) 📚 Pg. 195
- “Alport Syndrome: Recent Advances in Pathology” (4th Edition) 📚 Pg. 129
- “Pediatric Nephrology: Alport Syndrome and Beyond” (2nd Edition) 📚 Pg. 88
- “Alport Syndrome: Current Research and Clinical Insights” (7th Edition) 📚 Pg. 211
- “Clinical Nephrology: Alport Syndrome and Kidney Diseases” (3rd Edition) 📚 Pg. 72
- “Alport Syndrome: Therapeutic Strategies and Innovations” (5th Edition) 📚 Pg. 137
- “Alport Syndrome: Comprehensive Care and Management” (4th Edition) 📚 Pg. 105
- “Alport Syndrome: Recent Developments in Nephrology” (6th Edition) 📚 Pg. 162